Synthesis of 1, 3, 4-oxadiazole derivatives have attracted considerable attention in view of therapeutic applications. In the present research work, a series of 6-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-3aryl/heteryl[1,2,4]triazolo[3,4-\nb][1,3,4]oxadiazole compounds was synthesized by treating 1-[5-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-1,3,4-oxadiazol-2-\nyl] hydrazine with the corresponding acid chlorides. All the synthesized compounds have been characterized by using elemental\nanalysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has\nbeen checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were screened for their\nin-vitro anthelmintic and anti-microbial activity by standard methods. The compounds exhibited significant antimicrobial and\nanthelmintic activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and\nthe antimicrobial and anthelmintic screening of the new compounds were reported.
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